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- Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis
- Vitamin D Life pages with HIGH-DOSE in title (63 as of April 2022 - all ages)
- Vitamin D Life - Loading Doses for Infants-Children are effective and safe (
22 studies) - Vitamin D Life - Toxicity and Infants-Children (
7 studies) Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis
AMA Netw Open. 2022 Apr 1;5(4):e227410 doi: 10.1001/jamanetworkopen.2022.7410.
Nicklas Brustad 1, Sina Yousef 1, Jakob Stokholm 1 2, Klaus Bønnelykke 1, Hans Bisgaard 1, Bo Lund Chawes 1High- Dose Daily (<10,000 IU)
Bolus dose (<600,000 IU) note: Bolus taken over 1 - 60 days = Loading
Importance: Several health benefits of vitamin D have been suggested; however, the safety of high-dose supplementation in early childhood is not well described.Objective: To systematically assess the risk of adverse events after high-dose supplementation with vitamin D reported in published randomized clinical trials.
Data sources: PubMed and ClinicalTrials.gov were searched through August 24, 2021.
Study selection: Randomized clinical trials of high-dose vitamin D supplementation in children aged 0 to 6 years, defined as greater than 1000 IU/d for infants (aged 0-1 year) and greater than 2000 IU/d for children aged 1 to 6 years.Data extraction and synthesis: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline, 2 reviewers independently extracted the data from the eligible studies. Summary risk ratio (RR), 95% CI, and P values were derived from random-effects meta-analysis.
Main outcomes and measures: Adverse events, serious adverse events (SAEs), and/or levels of 25-hydroxyvitamin D, calcium, alkaline phosphatase, phosphate, parathyroid hormone, and/or the ratio of urine calcium to creatinine levels.Results: A total of 32 randomized clinical trials with 8400 unique participants were included. Different clinical outcomes of children receiving high-dose vitamin D supplements ranging from 1200 to 10 000 IU/d and bolus doses from 30 000 IU/week to a single dose of 600 000 IU were evaluated. Eight studies with 4612 participants were eligible for meta-analysis using a control group receiving either low-dose vitamin D supplementation (≤400 IU/d) or placebo when investigating the risk of SAEs such as hospitalization or death.
No overall increased risk of SAEs in the high-dose vitamin D vs control groups was found (RR, 1.01 [95% CI, 0.73-1.39]; P = .89, I2 = 0%).
In addition, risk of hypercalcemia (n = 726) was not increased (RR, 1.18 [95% CI, 0.72-1.93]; P = .51).
Clinical adverse events potentially related to the vitamin D supplementation reported in the studies were rare.Conclusions and relevance: This meta-analysis and systematic review found that high-dose vitamin D supplementation was not associated with an increased risk of SAEs in children aged 0 to 6 years, and that clinical adverse events potentially related to the supplementation were rare. These findings suggest that vitamin D supplementation in the dose ranges of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to young children may be well tolerated.
Summary clipped from PDF
"Thus, our findings suggest that vitamin D supplementation in the high-dose range of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to infants and preschool children to 6 years of age may be safe in both healthy children and in children with various diseases."
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Items found: 77Vitamin D Life - Loading Doses for Infants-Children are effective and safe (
22 studies) This list is automatically updated
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- Child soccer players who were deficient were helped by a single 200,000 IU vitamin D dose – RCT May 2020
- Infant Vitamin D doubles 6 months after birth (can double in 2 weeks)– Oct 2019
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- 2X improved development by severely malnourished children with 2 loading doses of vitamin D – RCT May 2018
- 100,000 IU Vitamin D weekly for 4 weeks is safe and effective for children – May 2019
- Vitamin D loading dose of 300,000 IU for children – 3 weeks with capsules, biscuits, injection – RCT Aug 2018
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Quick restoration of vitamin D in children – 10,000 IU per kg loading dose was not enough – Jan 2017
- Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016
- Pediatric trials of high dose vitamin D -163 are in a single online database – Feb 2016
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014
- Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 600,000 IU of vitamin D2 every 4 months for decades in East Germany – 1987
Vitamin D Life - Toxicity and Infants-Children (
7 studies) This list is automatically updated
- Vitamin D Toxicity with no long term problems starts at 300 ng (infant with 222 ng had no symptoms) – March 2022
- Vitamin D toxicity is extremely rare, accidental, and very mild in Iranian children – July 2020
- Infant hospitalized after Vitamin D overdose (8,000 X too much) Feb 2016
- Rare infant vitamin D toxicity – due to errors which resulted in more that 240,000 IU – Jan 2014
- Concern about accidentally giving infant too much liquid vitamin D – Aug 2012
- Dosing error gave 12000 IU daily vitamin D to infant, but no indication of any problem – April 2012
- CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity – Aug 2011
High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022(Cached) Printer Friendly Follow this page for updates2537 visitors, last modified 18 Jan, 2023, This page is in the following categories (# of items in each category)Attached files
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